產(chǎn)品貨號

CP008

反應種屬

Mouse

同種型

Mouse IgG2b(switched from mouse IgG2a)

實驗應用

in vivo CTLA-4 neutralization*

Western blot*

*Reported for the original mouse IgG2b 9D9 antibody

純度

>95%, Determined by SDS-PAGE

無菌處理

0.2 µm filtration

分子量

150 kDa

保存條件

抗體原液保存在4°C，不能冷凍保存。

體內(nèi)CTLA-4中和

(in vivo CTLA-4 

neutralization)

1. Dai, M., et al. (2015). 'Curing mice with large tumors by locally 

delivering combinations of immunomodulatory antibodies' 

Clin Cancer Res 21(5): 1127-1138.

2. Zippelius, A., et al. (2015). 'Induced PD-L1 expression mediates 

acquired resistance to agonistic anti-CD40 treatment' Cancer Immunol 

Res 3(3): 236-244.

3. Redmond, W. L., et al. (2014). 'Combined targeting of costimulatory 

(OX40) and coinhibitory (CTLA-4) pathways elicits potent effector T 

cells capable of driving robust antitumor immunity' Cancer Immunol 

Res 2(2): 142-153.

4. Condamine, T., et al. (2014). 'ER stress regulates myeloid-derived 

suppressor cell fate through TRAIL-R-mediated apoptosis' J Clin Invest 

124(6): 2626-2639.

5. Muller, P., et al. (2014). 'Microtubule-depolymerizing agents used in 

antibody-drug conjugates induce antitumor immunity by stimulation of 

dendritic cells' Cancer Immunol Res 2(8): 741-755.

6. Bulliard, Y., et al. (2013). 'Activating Fc gamma receptors contribute 

to the antitumor activities of immunoregulatory receptor-targeting 

antibodies' J Exp Med 210(9): 1685-1693.